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Results Effects of TLYY administration on body weight and pathological features in DSS-induced mice The DSS-induced colitis mouse model closely recapitulates the symptomatic manifestations of human ulcerative colitis, including reduced activity, body weight loss, diarrhea, and fecal occult blood

YSI, Yellow Springs, OH)

Furthermore, a similar scenario was observed in GMPs: both RSL3-treated and Gpx4 -depleted GMPs accumulated lipid peroxides and succumbed to ferroptosis (Supplementary Fig